We use PreadyPort MDR1 to identify the permeability of test articles and also to confirm if they were a substrate of the transporter and/or an inhibitor of the transporter. The kits were very helpful for us as culturing these cell lines manually is very time consuming, and prone to error - the ability to regularly order pre-cultured plates that were ready to use was extremely useful and we always received amazing support from the company when trying to set this assay up.

The barriers of the intestine take 21 days of differentiation before they are ready to be used for an experiment. With ReadyCell plates, we can use their models without the resource required to maintain Transwell cultures. This saves both time and resources. We have found MedTech Barcelona to be a professional service, with good batch quality of cells. Shipment takes a matter of days and we can use the barriers over a 5-day window once they arrive in the lab.

We use CacoReady as the cells during air transport are considered stable. This product has a high throughput due to the 96-well format, as well as a long experimental period (5 days) and no annual license requirement. We use it for investigational drug evaluation as a substrate and as an inhibitor of P-gp and BCRP.

CacoReady is a great ready-to-use kit for absorption, transporter and metabolism research. Due to its ease of use, it saves time in cell culture.

We have validated our permeability assay methodology using the CacoReady 24 kit and its reproducible and well accepted by regulatory agencies. We are using it for permeability classification of drug product which is one of the parameters for bio-waiver request package submitted to the regulatory agencies.

We use CacoReady because it streamlines our workflow by eliminating the need to culture and validate the monolayers ourselves. The assay-ready plates provide a convenient and reliable solution for bidirectional permeability studies, allowing us to focus our resources on experimental design and data analysis.

We use CacoReady with Transwell to evaluate intestinal permeability for drugs. The kit makes it possible to study A to B and B to A permeability and the calculation of the efflux ratio, intended for the selection of the most permeable candidates in different chemical series.

For our small team, the availability of the PreadyPort system to use as a screening assay is great. We save a lot of time we would otherwise use maintaining the cell cultures. We use it for permeability and efflux DMPK screens of small molecule compounds.

Ease of ordering, consistent results, and a high-quality product for when we aren’t able to use our own in-house cells. We use CacoReady for determining the effects of a client’s compound on the efflux of known Pgp and BCRP control substrates as well as the permeability of the client compound.