Ready-to-use in vitro kits for drug discovery
The ReadyCell product line from MedTech Barcelona offers ready-to-use cell-based plates that maximize efficacy and safety testing of new molecular entities during preclinical drug discovery and development.
Get detailed insights on our transporter assays
Worldwide shipments at room temperature thanks to our patented technology
Products conceived according to main regulatory agencies’ requirements
Free consultation and technical support during the assay and in bio-analytics.
READY-TO-USE MODELS
Caco-2 Cell Kits
24 or 96 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 cells. This cell model is considered to be the gold standard for assessing intestinal permeability of new oral drugs in in vitro preclinical studies, according to leading regulatory agencies.
We recommend acquiring this product together with the CacoReady Cell Culture Medium to ensure optimal performance and reproducibility.
24 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 and HT-29 cells with an absorptive and mucus-secreting phenotype, respectively. This co-culture model enables the evaluation of anti-inflammatory drug efficacy by assessing cellular responses to inflammatory mediators. Additionally, its physiologically relevant barrier allows for studying in intestinal absorption of drug candidates.
We recommend acquiring this product together with the CacoGoblet Cell Culture Medium to ensure optimal performance and reproducibility.
MDCKII Cell Kits
24 and 96 transwell insert plates cultured with the 12 days differentiated MDCKII parental cell line. A reference in vitro model to evaluate passive permeation of orally administered drugs. It also serves as the control for PreadyPort MDR1 and PreadyPort BCRP, enabling the assessment of drug transport by comparing results with these efflux transporter models.
We recommend acquiring this product together with the MDCKII Cell Culture Medium to ensure optimal performance and reproducibility.
24 or 96 transwell insert plates cultured with 12 days differentiated MDR1-overexpressing MDCKII cells. The MDR1 efflux transporter has an ubiquitous tissue distribution, with a critical role in intestinal absorption, biliary and urinary excretion of drugs and in the entry of active molecules into the central nervous system.
We recommend acquiring this product together with the MDCKII Cell Culture Medium to ensure optimal performance and reproducibility.
24 or 96 transwell insert plates cultured with 12 days differentiated BCRP-overexpressing MDCKII cells. BCRP is a high-capacity efflux transporter with broad substrate specificity. It is located in the apical cell membrane of barrier tissues and excretory organs.
We recommend acquiring this product together with the MDCKII Cell Culture Medium and the Protein Expression Medium to ensure optimal performance and reproducibility.
Customize your plates by choosing either MDCKII cells or HEK293 cells overexpressing efflux and uptake transporters respectively, according to the assay requirements.
HEK293 Cell Kits
96 multiwell insert plates with differentiated MATE1-overexpressing HEK293 cells. Drug-transporter interactions involving MATE1 may compromise drug renal clearance and biliary excretion.
96 multiwell insert plates with differentiated OCT2-overexpressing HEK293 cells. The OCT2 transporter carries a wide range of different solutes across biological membranes, being especially relevant for those drugs that are renally excreted.
96 multiwell insert plates with differentiated HEK 293 cells expressing OATP1B3 as well as the parental cell line. Because of these transporters’ prominent expression on the sinusoidal membrane of hepatocytes, OATP1B3 represents a critical mechanism for the uptake of drugs into the liver.
At MedTech Barcelona we provide all necessary and appropriate solutions for each assay to efficiently ease your screening.
| Product | Size | Catalog # | Shipping |
|---|---|---|---|
| CacoReady Cell Culture Medium | 500 mL | S-CACO-M500 | Room Temperature |
| CacoGoblet Cell Culture Medium | 500 mL | S-CCCB-M500 | Room Temperature |
| MDCKII Cell Culture Medium | 500 mL | S-MDCK-M500 | Room Temperature |
| Assay Buffer | 500 mL | S-HBSS500 | Room Temperature |
| Protein Expression Medium | 150 mL | S-MDCK-SB150 | Room Temperature |
Rely on specialized support from an experienced team and get the highest quality of kits for a perfect replicability of in vitro assays.
Biotechnology company specialized in the development and commercialization of innovative solutions for the pharmaceutical industry and biomedical research.
