Blog - ReadyCell by MedTech Barcelona

07/04/2025

CacoGoblet anti-inflammatory testing protocol

The CacoGoblet model offers a fast and reliable approach to in vitro anti-inflammatory drug testing. By assessing TEER and paracellular permeability, this assay provides key insights into intestinal inflammation and compound efficacy.

Inflammation

02/04/2025

Recommended reference compounds for permeability assays

Permeability assays are important for understanding how molecules cross biological barriers, assessing both their ability to cross and the mechanisms involved. While drugs are often absorbed by passive diffusion, some molecules can also be substrates for membrane proteins or transporters.

Permeability, Regulatory Compliance, Research & Development

18/03/2025

CacoReady Permeability test, used to study a novel treatment against malignant cells

A study led by scientist Andrew Novak and published last November in the prestigious Journal of Medicinal Chemistry explored a new therapeutic approach targeting malignant cell proliferation.

Permeability, Research & Development

15/02/2025

Cytotoxicity Assay Protocol

Explore our comprehensive cytotoxicity assay protocol featuring advanced testing methods with CacoReady kits. Learn about TEER, LY flux, and how to predict drug toxicity effectively.

Cytotoxicity & Toxicology, Research & Development

20/11/2024

Caco-2 Permeability Assay Protocol

The permeability assay protocol for Caco-2 cells serves as a cornerstone in understanding and predicting the intestinal absorption of pharmaceutical agents.

Permeability, Regulatory Compliance, Research & Development

10/10/2024

A pioneering investigation unveils allosteric SHP2 inhibitors for cancer therapy

In a publication in the Journal of Medicinal Chemistry, a collaborative research led by the scientist Dr. H. Day, in conjunction with a consortium of researchers, explored the development of allosteric inhibitors targeting SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) for cancer therapy.

Permeability, Research & Development

28/09/2024

Guide to select the right well system for your research

In preclinical research, the choice of the appropriate well system format – whether it's a transwell, non-transwell, or individual transwell – can significantly impact the outcome of experiments. Selecting the correct plate is crucial to working with permeability, toxicity, drug screening, or other assays.

Blood Brain Barrier, Cytotoxicity & Toxicology, Drug-Transporter Interactions, Efflux Transporters, Inflammation, Permeability, Regulatory Compliance, Research & Development, Uptake Transporters

14/05/2024

Shipping Medium, an innovative solution for in vitro cell preservation

MedTech Barcelona’s shipping medium enables safe and cost-effective in vitro cell transport at room temperature for global shipments

Research & Development

06/03/2024

Advancements in β-Glucocerebrosidase Modulation: New Therapeutics for Gaucher’s Disease

This research, titled Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase, highlights the potential of fragment-based drug discovery (FBDD) and employs permeability assays with CacoReady and PreadyPort plates.

Drug-Transporter Interactions, Efflux Transporters, Permeability, Research & Development

01/03/2024

Cell-based in vitro models to characterize Food-Drug Interactions

It is well known that food intake changes luminal conditions in the stomach and the small intestine, modifying drug bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.

Drug-Transporter Interactions

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