The primary goal of this project is to develop liver-on-chip systems that integrate microfluidics, 3D printing, human-derived liver cells, and liver-derived bioinks.
The article highlights the discovery of a series of azetidine derivatives, known as BGAz compounds, that exhibit potent bactericidal activity against both drug-sensitive Mycobacterium tuberculosis and multidrug-resistant TB strains.
The Blood-Brain Barrier (BBB) is a highly selective barrier that regulates the exchange of substances between the bloodstream and the central nervous system (CNS). It consists of endothelial cells, pericytes, astrocytes, and neurons, forming what is known as the neurovascular unit.
In a study published in the Future Pharmacology Journal, researchers from prestigious French companies examined the impact of four polyols on the permeability of seven active pharmaceutical ingredients (APIs).
Discover the role of hepatic and renal transporters in drug clearance. Our in vitro assays help assess drug elimination pathways and drug-drug interactions efficiently.
An investigation led by the researcher Nicoló Milani was published in the prestigious analytical journal Lab on a Chip. The ReadyCell CacoGoblet kit was employed to investigate the permeability and the metabolism of the compound in a gut-liver-organ-on-a-chip (OoC).
In this review, we explore the most used in vitro models for evaluating intestinal permeability, from Caco-2 cells to advanced gut-on-a-chip technologies. Understand how these models help optimize drug discovery and assess gastrointestinal absorption.
Evaluating in vitro permeability with CacoReady plates was central to the study design. By quantifying the permeability of the synthesized compounds within Caco-2 cells, researchers could identify and select which compounds were best in terms of cellular adsorption.
The presence of the superfamily members of the ATP binding cassette (ABC) transporters is well established as the main cause of multidrug resistance, since they efflux therapeutic compounds from cells and reduce the intracellular drug levels.
The publication, entitled Daily Intraperitoneal Administration of RGZ Does Not Improve Lung Function or Alveolarization in Preterm Rabbits Exposed to Hyperoxia, was aimed at testing the efficacy of three types of Thiazolidenoides (TZN) in preterm rabbits with bronchopulmonary dysplasia.
